[ 18 F]F-AraG Uptake in Vertebral Bone Marrow May Predict Survival in Patients with Non–Small Cell Lung Cancer Treated with Anti-PD-(L)1 Immunotherapy

作者：Jelena Levi, Millie Das, Minal Vasanawala, Deepti Behl, Martin G. Pomper, Patrick M. Forde, Erica C. Nakajima, James Sayre, Bin Shen, Hilda Cabrera, Niko Del Mar, Michele Gullen, Michele Pierini, Laura A. Cox, Ojaswita Lokre, Timothy Perk, Hee-Don Chae · 发表于：Journal of Nuclear Medicine · 年份：2024 · DOI：10.2967/jnumed.124.268253 · 被引用次数：6 · 研究领域：Cancer Immunotherapy and Biomarkers、Medical Imaging Techniques and Applications、Cancer, Hypoxia, and Metabolism

Despite the systemic impact of both cancer and the associated immune response, immuno-PET is predominantly centered on assessment of the immune milieu within the tumor microenvironment. The aim of this study was to assess the value of [ 18 F]F-AraG PET imaging as a noninvasive method for evaluation of system-wide immune status of patients with non–small cell lung cancer before starting immunotherapy. Methods: Eleven patients with advanced non–small cell lung cancer were imaged with [ 18 F]F-AraG before starting immunotherapy. Diagnostic [ 18 F]FDG PET/CT scans were analyzed to assess differences in the extent of disease among patients. SUV max , SUV mean , and total SUV (SUV total ) from all tumor lesions, active lymph nodes, spleen, vertebral bone marrow, liver, thyroid, heart, and bowel were extracted from the baseline [ 18 F]F-AraG scans, and discriminant and Kaplan–Meier analyses were performed to test their ability to predict patient response and overall survival. Results: The extent of the disease was variable in the patient cohort, but none of the [ 18 F]FDG biomarkers associated with tumor burden (SUV max , total metabolic tumor volume, and total lesion glycolysis) was predictive of patient survival. The differences in the [ 18 F]F-AraG and [ 18 F]FDG distribution were observed both within and between lesions, confirming that they capture distinct aspects of the tumor microenvironment. Of the 3 SUV parameters studied, [ 18 F]F-AraG SUV total provided a dynamic ra...