High Fischer ratio oligopeptides from Antarctic krill: Ameliorating function and mechanism to alcoholic liver injury through regulating AMPK/Nrf2/IκBα pathways

作者：Xiaomeng Dong, Shikun Suo, Yumei Wang, Yu-Hui Zeng, Chang‐Feng Chi, Bin Wang · 发表于：Journal of Functional Foods · 年份：2024 · DOI：10.1016/j.jff.2024.106537 · 被引用次数：49 · 研究领域：Alcohol Consumption and Health Effects、Diet, Metabolism, and Disease、Liver Disease Diagnosis and Treatment

• NIAAA method was used to establish a mouse model of alcoholic liver injury (ALI). • Protective mechanism of high Fischer ratio oligopeptides from Antarctic krill (HFOPs-AK) on ALI mice was studied. • HFOPs-AK could modulate lipid metabolism, anti-inflammatory and antioxidant effects. • Protective mechanism of HFOPs-AK is to regulate the AMPK/Nrf2/IκBα signaling pathways. In this study, we devoted attention to the hepatoprotective functions of high Fischer ratio oligopeptides (HFOPs) from Antarctic krill (HFOPs-AK) on alcoholic liver injury of mice. The results indicated that HFOPs-AK significantly improved the pathological state of mice liver and kidney, reduced alanine aminotransferase (ALT) and aspartate transaminase (AST) activities, regulated lipid metabolism, and alleviated the burden on the liver. In addition, HFOPs-AK depicted anti-inflammatory and antioxidant effects by reducing tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) contents and increasing superoxide dismutase (SOD) and catalase (CAT) activities to reduce malondialdehyde (MDA) level. The hepatoprotective mechanism of HFOPs-AK was further revealed by quantitative reverse transcription PCR (RT-qPCR) analysis, and the results proved that HFOPs-AK had the ability to stimulate the adenosine 5‘-monophosphate-activated protein kinase (AMPK)/nuclearrespiratoty factor 2 (Nrf2)/inhibitor of NF-κB (IκBα) signaling pathways, thereby regulating the expression levels of downstream factors. The activation of the...