Screening Model for Bladder Cancer Early Detection With Serum miRNAs Based on Machine Learning: A Mixed‐Cohort Study Based on 16,189 Participants

作者：Cong Lai, Zhensheng Hu, Jintao Hu, Zhuohang Li, Lin Li, Mimi Liu, Zhikai Wu, Yi Zhou, Cheng Liu, Kewei Xu · 发表于：Cancer Medicine · 年份：2024 · DOI：10.1002/cam4.70338 · 被引用次数：8 · 研究领域：Bladder and Urothelial Cancer Treatments、Urinary Tract Infections Management、Urinary Bladder and Prostate Research

BACKGROUND: Early detection of bladder cancer (BCa) can have a positive impact on patients' prognosis. However, there is currently no widely accepted method for early screening of BCa. We aimed to develop an efficient, clinically applicable, and noninvasive method for the early screening of BCa by detecting specific serum miRNA levels. METHODS: A mixed-cohort (including BCa, 12 different other cancers, benign disease patients, and health population) study was conducted using a sample size of 16,189. Five machine learning algorithms were utilized to develop screening models for BCa using the training dataset. The performance of the model was evaluated using receiver operating characteristic curve and decision curve analysis on the testing dataset, and subsequently, the model with the best predictive power was selected. Furthermore, the selected model's screening performance was evaluated using both the validation set and external set. RESULTS: The BCaS3miR model, utilizing only three serum miRNAs (miR-6087, miR-1343-3p, and miR-5100) and based on the KNN algorithm, is the superior screening model chosen for BCa. BCaS3miR consistently performed well in both the testing, validation, and external sets, exceeding 90% sensitivity and specificity levels. The area under the curve was 0.990 (95% CI: 0.984-0.991), 0.964 (95% CI: 0.936-0.984), and 0.917 (95% CI: 0.836-0.953) in the testing, validation, and external set. The subgroup analysis revealed that the BCaS3miR model demonstrated...