Prevalence, Phenotypes, and Comorbidities of Polycystic Ovary Syndrome Among Indian Women

作者：Mohd Ashraf Ganie, Subhankar Chowdhury, Neena Malhotra, Rakesh Sahay, Prasanta Kumar Bhattacharya, Sarita Agrawal, Puthiyaveettil Khadar Jabbar, Vanita Suri, Roya Rozati, Vishnubhatla Sreenivas, Mohammad Salem Baba, Imtiyaz Ahmad Wani, Haroon Rashid, Abhilash Nair, Amlin Shukla, Taruna Arora, Bharati Kulkarni, PCOS Study Group, Parvaiz A Koul, Zafar A. Shah, Shariq Rashid Masoodi, Tabasuum Parvez, Ghulam Nabi Yatoo, Naseer Ahmad Chow, Tariq Gojwari, Muzaffar Wani, Seema Qayoom, Wahid Ali Khan, Rama Walia, Deepenkar De, Aashima Arora, Tulika Singh, Neena Khanna, Nitish Naik, Shyam Prakash, Nandita Gupta, Rajesh Sagar, Jai Bhagwan Sharma, Devasenathipathy Kandasamy, Narender Kuber Bodhey, Eli Mohapatra, Sabah Siddiqui, Gourisankar Kamilya, Archana Singh, Pradip Mukhopadhyay, Nehar Ranjan Sarkar, Alice Abraham Ruram, Jessy Abraham, Donboklang Lynser, Manika Agrawal, Laksman Rao, Sudha Bindu, Malathi Ponnuru, Nadeem Ahmad, Sujatha Rani, Aleem Ahmad Khan, Sultan Rizwan Ahmad, Prabhakar Rao, Nirmala Chongtham, Anuja Elizabeth George, Jayasree Leelamma, Gaurav Thakur, Saba Noor, Khursheed Paddar, Gaivee Vinam Meshram, Shouvik Choudhary, Aafia Rashid, Wasia Showkat, Rohina Bashir, Rabiya Rashid, Jabish Manzoor, Nisar Ahmad, Pieu Adhikary, Subhasish Pramanik, Rahul Harish, Mudasir Makhdoomi, Mudasir Fayaz, Nafeez Rehman, Neha Ravi, Ajay Kumar, Siffali Chandrakar, Nithlesh Kumar, Sudipta Banerjee, Humaira Minhaj, B. Bhaskar, Shaik Iqbal, Ram Babu, Arya Suresh, RS Sharma, Shalini Singh, Malabika Roy, Reeta Rasilly, Nomita Chandiok, M. Rajab, Arifa Reshi, Deeba Farhat, Abid Rashid, Nusrat Jahan, Shavini Choudhary, Naila Mohiudin, Samala Ranjith, Khalid Ul Islam Rather · 发表于：JAMA Network Open · 年份：2024 · DOI：10.1001/jamanetworkopen.2024.40583 · 被引用次数：52 · 研究领域：Ovarian function and disorders、Ovarian cancer diagnosis and treatment、Gynecological conditions and treatments

Importance: The prevalence of polycystic ovary syndrome (PCOS) varies across the globe. Indian studies on PCOS are limited by poor design, small sizes, regional representations, and varying methods. Objectives: To estimate the nationwide prevalence of PCOS in India, examine the phenotypic spectrum, and assess the magnitude of comorbidities associated with PCOS. Design, Setting, and Participants: This cross-sectional study recruited 9824 women aged 18 to 40 years from November 1, 2018, to July 31, 2022, across 5 zones of the country. A prevalidated questionnaire dichotomized women into screen-positive and screen-negative groups. Relevant clinical, hormonal, and sonographic assessments categorized women as either women with criteria-based PCOS (ie, National Institutes of Health [NIH] 1990 criteria, Rotterdam 2003 criteria, or Androgen Excess and Polycystic Ovary Syndrome Society [AE-PCOS] criteria), women with partial phenotypes (hyperandrogenism, oligomenorrhea, or polycystic morphology labeled as pre-PCOS), or healthy women, in addition to quantitating various comorbidities. Main Outcomes and Measures: The prevalence and phenotypes of PCOS among women of reproductive age and the burden of comorbidities associated with PCOS. Results: A total of 8993 women (mean [SD] age, 29.5 [6.2] years) were enrolled in this study; 196 women were already diagnosed with PCOS, 2251 were categorized as screen positive, and 6546 were categorized as screen negative. The mean (SD) age of screen-po...