Use of UMFNPs/Ce6@MBs in multimodal imaging-guided sono-photodynamic combination therapy for hepatocellular carcinoma

作者：Lijun Xing, Xiaoting Yang, Jianhua Bai, Chunting Zhong, Jing Cai, Qing Dan, Yiran Ji, Bingxuan Xu, Keyan Yu, Xiaoyu Chen, Yulong Qi, Li Li, Yun Chen, Xintao Shuai, Guanxun Cheng, Li Liu, Tingting Zheng · 发表于：Biomaterials Science · 年份：2024 · DOI：10.1039/d4bm00613e · 被引用次数：9 · 研究领域：Nanoplatforms for cancer theranostics、Photodynamic Therapy Research Studies、Hepatocellular Carcinoma Treatment and Prognosis

magnetic resonance imaging of tumor-bearing mice, and the released Ce6 can provide fluorescence imaging function at the same time. Because UMFNPs/Ce6@MB ultrasonic microbubbles show good ultrasonic imaging results, UMFNPs/Ce6@MBs can simultaneously provide multi-modal imaging functions for magnetic resonance imaging (MRI), ultrasound and fluorescence imaging. In conclusion, UMFNPs/Ce6@MBs realize the synergistic treatment of SDT and PDT under multi-mode near-infrared fluorescence imaging and CEUS monitoring, demonstrating its great potential in tumor precision medicine.