Molecular architecture of monkeypox mature virus

作者：Ye Hong, Baoying Huang, Junxia Zhang, Cheng Peng, Weizheng Kong, Wenjie Tan, Sai Li · 发表于：Cell Discovery · 年份：2024 · DOI：10.1038/s41421-024-00741-5 · 被引用次数：15 · 研究领域：Poxvirus research and outbreaks、Plant Virus Research Studies、Herpesvirus Infections and Treatments

The mpox outbreak since 2022 has caused over 106,310 lab-confirmed infected cases with 234 deaths across 123 countries/territories/areas and was declared a public health emergency of international concern (PHEIC) by the World Health Organization in 2022 and again in 2024. The causative pathogen, monkeypox virus (MPXV), is a zoonotic double-stranded DNA (dsDNA) orthopoxvirus encoding 181 proteins 1 . Although smallpox vaccines based on vaccinia virus (VACV) could provide cross-protection against MPXV infection and have been used for current mpox prevention, no licensed specific vaccine or medicine against MPXV is available globally 2 .