RMVar 2.0: an updated database of functional variants in RNA modifications

作者：Yuantai Huang, Luowanyue Zhang, Weiping Mu, Mohan Zheng, Xiaoqiong Bao, Huiqin Li, Xiaotong Luo, Jian Ren, Zhixiang Zuo · 发表于：Nucleic Acids Research · 年份：2024 · DOI：10.1093/nar/gkae924 · 被引用次数：20 · 研究领域：RNA modifications and cancer、RNA and protein synthesis mechanisms、Cancer-related molecular mechanisms research

Evaluating the impact of genetic variants on RNA modifications (RMs) is crucial for identifying disease-associated variants and understanding the pathogenic mechanisms underlying human diseases. Previously, we developed a database called RMVar to catalog variants linked to RNA modifications in humans and mice. Here, we present an updated version RMVar 2.0 (http://rmvar.renlab.cn). In this updated version, we applied an enhanced analytical pipeline to the latest RNA modification datasets and genetic variant information to identify RM-associated variants. A notable advancement in RMVar 2.0 is our incorporation of allele-specific RNA modification analysis to identify RM-associated variants, a novel approach not utilized in RMVar 1.0 or other comparable databases. Furthermore, the database offers comprehensive annotations for various molecular events, including RNA-binding protein (RBP) interactions, RNA-RNA interactions, splicing events, and circular RNAs (circRNAs), which facilitate investigations into how RM-associated variants influence post-transcriptional regulation. Additionally, we provide disease-related information sourced from ClinVar and GWAS to help researchers explore the connections between RNA modifications and various diseases. We believe that RMVar 2.0 will significantly enhance our understanding of the functional implications of genetic variants affecting RNA modifications within the context of human disease research.