Reproducibility of ultrasound-derived fat fraction in measuring hepatic steatosis

作者：Danlei Song, Pingping Wang, Jiahao Han, Huihui Chen, Ruixia Gao, Ling Li, Jia Li · 发表于：Insights into Imaging · 年份：2024 · DOI：10.1186/s13244-024-01834-1 · 被引用次数：16 · 研究领域：Liver Disease Diagnosis and Treatment、Body Composition Measurement Techniques、Nutrition and Health in Aging

PURPOSE: Steatotic liver disease (SLD) has become the most common cause of chronic liver disease. Nevertheless, the non-invasive quantitative diagnosis of steatosis is still lacking in clinical practice. This study aimed to evaluate the reproducibility of the new parameter for steatosis quantification named ultrasound-derived fat fraction (UDFF). MATERIALS AND METHODS: The UDFF values were independently executed by two operators in two periods. In the process, repeated measurements of the same patient were performed by the same operator under different conditions (liver segments, respiration, positions, and dietary). Finally, the results of some subjects (28) were compared with the MRI-derived proton density fat fraction (PDFF). The concordance analysis was mainly achieved by the intraclass correlation coefficient (ICC) and Bland-Altman. RESULTS: = 0.94). Meanwhile, the ICC of the two operators increased over time. The variable measurement states did not influence the UDFF values on the surface, but they affected the coefficient of variation (Cov) of the results. Segment 8 (S8), end-expiratory, supine, and fasting images had the most minor variability. On the other hand, the UDFF value of S8 displayed satisfied consistency with PDFF (mean difference, -0.24 ± 1.44), and the results of both S5 (mean difference: -0.56 ± 3.95) and S8 (mean difference: 0.73 ± 1.87) agreed well with the whole-liver PDFF. CONCLUSION: UDFF measurements had good reproducibility. Furthermore, the state...