Aging and senescent fates of oligodendrocyte precursor cells in the mouse brain

作者：P. Gómez, Chase M. Carver, Sonia L. Rodriguez, Liguo Wang, Xu Zhang, Marissa Schafer · 发表于：npj Aging · 年份：2024 · DOI：10.1038/s41514-024-00176-y · 被引用次数：23 · 研究领域：Neurogenesis and neuroplasticity mechanisms、Neuroinflammation and Neurodegeneration Mechanisms、MicroRNA in disease regulation

Age-related changes in oligodendrocyte precursor cells (OPCs) contribute to white matter dysfunction. In aged mice, we hypothesized that myelin-dense fimbria OPCs possess niche-specific properties, compared to hippocampal OPCs. Aged fimbria OPCs were fewer, larger, and localized to neighboring microglia. We identified age-increased p16/Cdkn2a-expressing OPCs enriched for senescence-related pathways and distinct senescence signatures between hippocampus and fimbria. Aged brain OPC populations differ in microenvironment properties and responses to senescence-directed intervention.