Roles of oral and gut microbiota in acute myocardial infarction

作者：Yulin Li, Bo‐Yan Chen, Zehao Feng, Lu-Jun Zhou, Ting Liu, Wen-Zhen Lin, Hong Zhu, Shuo Xu, Xuebing Bai, Xiao-Qian Meng, Zhang Jun, Yan Liu, Jun Pu, Meng Jiang, Sheng‐Zhong Duan · 发表于：Journal of Advanced Research · 年份：2024 · DOI：10.1016/j.jare.2024.10.009 · 被引用次数：13 · 研究领域：Oral microbiology and periodontitis research、Gut microbiota and health、Clostridium difficile and Clostridium perfringens research

• We discovered that the oral/gut microbial diversity and composition of AMI patients significantly different from control subjects. • We explored the associations between microbiota and clinical parameters of myocardial infarction. • We identified potential key microbiota in AMI process. • We discovered the oral-gut transmission of Streptococcus genus which aggravated experimental myocardial infarction in mice. • As a common genus in the oral cavity, Streptococcus species may have a significant impact on human health. The significance of oral/gut microbiota in acute myocardial infarction (AMI) has been increasingly appreciated. However, correlations between oral/gut microbiota and AMI parameter, as well as the key microbiota that may have a crucial function in this process, remain unclear. To investigate the composition and structure of oral and gut microbiota associated with AMI and explore the roles of specific bacterial species in the progression of AMI. We conducted a case-control study with 37 AMI patients and 36 controls. Oral and gut sample were collected and sequenced. Using correlation analysis, we combined bioinformatics data with AMI clinical parameters and obtained heatmaps of correlation coefficients. Additionally, we used antibiotics to eliminate the gut microbiota of C57BL/6J mice, followed by the transplantation of selected bacteria to verify the gut colonization of oral bacteria and their impact on AMI. The component of oral and gut microbiota of AMI group s...