Analysis of Mycoplasma pneumoniae pneumonia and viral coinfection in southern Guangzhou after the COVID-19 pandemic

作者：Xiongting Wu, Rong Chen, Di Mo, Yinyan Wang, Xia Yu, Mengzhang He · 发表于：Journal of Thoracic Disease · 年份：2024 · DOI：10.21037/jtd-24-729 · 被引用次数：11 · 研究领域：Respiratory viral infections research、Pneumonia and Respiratory Infections、COVID-19 Clinical Research Studies

Background: pneumonia (MPP) after the coronavirus disease 2019 (COVID-19) pandemic in southern Guangzhou. Methods: We reviewed 3,094 patients with respiratory infection who visited the respiratory medicine and pediatrics department from October 2023 to January 2024. Patients underwent polymerase chain reaction (PCR) or immunoglobulin M (IgM) serology for MP, influenza virus (IFV), respiratory syncytial virus (RSV), adenovirus (ADV) and enterovirus (EV). We further compared the clinical, laboratory, and imaging findings of the MPP patients with and without viral coinfection. In order to identify the significant association with viral coinfection in MPP, multivariable logistic regression analysis was performed. Results: MP infection was identified in 746 (36.69%) children and 140 (13.20%) adults, and there were 308 (41.29%) children and 76 (54.29%) adults with MPP. Eighty-four (27.27%) children and 7 (5.0%) adults with MPP had viral coinfection. Viral coinfection including MPP-RSV (4.22%), MPP-ADV (4.22%), MPP-EV (7.14%) and MPP-IFV (11.68%) was identified in children. These patients had a higher frequency of fever, higher white blood cell, higher concentration of C-reactive protein and procalcitonin, and higher proportion of lactate dehydrogenase (LDH) at greater than 250 U/L. Imaging feature of consolidation and air bronchogram sign was observed in both MPP and viral coinfection. Multivariable analysis showed fever (adjusted odds ratio, 3.46; 95% confidence interval, 1.02-11....