Bioactive metabolites: A clue to the link between MASLD and CKD?

作者：Wen‐Ying Chen, Jiahui Zhang, Lili Chen, Christopher D. Byrne, Giovanni Targher, Liangping Luo, Yan Ni, Ming‐Hua Zheng, Dan‐Qin Sun · 发表于：Clinical and Molecular Hepatology · 年份：2024 · DOI：10.3350/cmh.2024.0782 · 被引用次数：23 · 研究领域：Liver Disease Diagnosis and Treatment、Diet and metabolism studies

Metabolites produced as intermediaries or end-products of microbial metabolism provide crucial signals for health and diseases, such as metabolic dysfunction-associated steatotic liver disease (MASLD). These metabolites include products of the bacterial metabolism of dietary substrates, modification of host molecules (such as bile acids [BAs], trimethylamine-N-oxide, and short-chain fatty acids), or products directly derived from bacteria. Recent studies have provided new insights into the association between MASLD and the risk of developing chronic kidney disease (CKD). Furthermore, alterations in microbiota composition and metabolite profiles, notably altered BAs, have been described in studies investigating the association between MASLD and the risk of CKD. This narrative review discusses alterations of specific classes of metabolites, BAs, fructose, vitamin D, and microbiota composition that may be implicated in the link between MASLD and CKD.