Subthalamic Nucleus Deep Brain Stimulation for Meige Syndrome: Long-Term Outcomes and Analysis of Prognostic Factors

作者：Wentao Zheng, Qingpei Hao, Xi Chen, Yezu Liu, Zihao Zhang, Zhangyu Li, Jianyao Mao, Liwei Zhou, Sifang Chen, Guowei Tan, Ruen Liu · 发表于：Neurosurgery · 年份：2024 · DOI：10.1227/neu.0000000000003228 · 被引用次数：5 · 研究领域：Neurological disorders and treatments、Transcranial Magnetic Stimulation Studies、Parkinson's Disease Mechanisms and Treatments

BACKGROUND AND OBJECTIVES: The aim of this study was to explore the impacts of subthalamic nucleus deep brain stimulation (STN-DBS) on both motor and nonmotor symptoms in individuals with Meige syndrome, as well as further investigates prognostic factors for long-term postoperative outcomes. METHODS: We retrospectively reviewed a consecutive cohort of patients with intractable Meige syndrome who underwent STN-DBS at our center from January 2016 to July 2023. Motor function, quality of life, neuropsychological status, and mood state were evaluated with standardized scales at baseline and every 3 to 6 months thereafter. Univariate and multivariate linear regression analyses were used to determine independent risk factors that affect long-term motor function after STN-DBS. RESULTS: Fifty-five patients were ultimately analyzed with a mean follow-up of 62.1 ± 25.7 months. At the final postoperative assessment, movement and disability scores of the Burke-Fahn-Marsden Dystonia Rating Scale demonstrated improvements of 61% ( P < .001) and 57% ( P < .001), respectively. Postoperative scores on the 36-item Short-Form General Health Survey showed significant improvement from baseline. Global cognitive function and neuropsychological status remained stable during continuous neurostimulation. Multivariate linear regression analysis revealed that longer disease duration (standardized β coefficient = -0.294, 95% CI -0.039 to -0.007, P = .006), older age at surgery (standardized β coefficien...