Relationship between MRI brain-age heterogeneity, cognition, genetics and Alzheimer’s disease neuropathology

作者：Mathilde Antoniades, Dhivya Srinivasan, Junhao Wen, Guray Erus, Ahmed Abdulkadir, Elizabeth Mamourian, Randa Melhem, Gyujoon Hwang, Yuhan Cui, Sindhuja Tirumalai Govindarajan, Andrew A. Chen, Zhen Zhou, Zhijian Yang, Jiong Chen, Raymond Pomponio, Susan Sotardi, Yang An, Murat Bilgel, Pamela LaMontagne, Ashish Singh, Tammie L.S. Benzinger, Lori L. Beason‐Held, Daniel S. Marcus, Kristine Yaffe, Lenore J. Launer, John C. Morris, Duygu Tosun, Luigi Ferrucci, R. Nick Bryan, Susan M. Resnick, Mohamad Habes, David A. Wolk, Yong Fan, Ilya M. Nasrallah, Haochang Shou, Christos Davatzikos · 发表于：EBioMedicine · 年份：2024 · DOI：10.1016/j.ebiom.2024.105399 · 被引用次数：13 · 研究领域：Dementia and Cognitive Impairment Research、Functional Brain Connectivity Studies、Advanced MRI Techniques and Applications

BACKGROUND: Brain ageing is highly heterogeneous, as it is driven by a variety of normal and neuropathological processes. These processes may differentially affect structural and functional brain ageing across individuals, with more pronounced ageing (older brain age) during midlife being indicative of later development of dementia. Here, we examined whether brain-ageing heterogeneity in unimpaired older adults related to neurodegeneration, different cognitive trajectories, genetic and amyloid-beta (Aβ) profiles, and to predicted progression to Alzheimer's disease (AD). METHODS: Functional and structural brain age measures were obtained for resting-state functional MRI and structural MRI, respectively, in 3460 cognitively normal individuals across an age range spanning 42-85 years. Participants were categorised into four groups based on the difference between their chronological and predicted age in each modality: advanced age in both (n = 291), resilient in both (n = 260) or advanced in one/resilient in the other (n = 163/153). With the resilient group as the reference, brain-age groups were compared across neuroimaging features of neuropathology (white matter hyperintensity volume, neuronal loss measured with Neurite Orientation Dispersion and Density Imaging, AD-specific atrophy patterns measured with the Spatial Patterns of Abnormality for Recognition of Early Alzheimer's Disease index, amyloid burden using amyloid positron emission tomography (PET), progression to mild c...