Gut microbiota in women with polycystic ovary syndrome: an individual based analysis of publicly available data

作者：Yanan Yang, Jiale Cheng, Chongyuan Liu, Xiaopo Zhang, Ning Ma, Zhi Zhou, Weiying Lu, Chongming Wu · 发表于：EClinicalMedicine · 年份：2024 · DOI：10.1016/j.eclinm.2024.102884 · 被引用次数：45 · 研究领域：Ovarian function and disorders、Gut microbiota and health、Reproductive tract infections research

Background Polycystic ovary syndrome (PCOS) represents a prevalent endocrine disorder affecting numerous females worldwide. Dysbiosis of gut microbiota has been linked to the occurrence of PCOS; however, research into the characteristics of gut microbiota in PCOS patients, especially those from different regions and with different testosterone level, remains limited. Additionally, it is still unclear whether gut microbiota helps to distinguish different PCOS subtypes. Methods We searched four electronic databases (PubMed, Web of Science, Cochrane Library, and ClinicalTrials.gov) from Jan 1, 2010 to May 1, 2024. This combined analysis included studies providing the raw data of gut microbiota in PCOS patients. We reanalyzed the characteristics of gut microbiota in PCOS patients from different regions and with different testosterone level. Findings Fourteen publications satisfying the inclusion criteria were included in the combined analysis. Based on data from 948 individuals, we found alpha-diversity was not significantly different between PCOS and healthy control (HC) groups. However, gut microbiota composition was distinct in PCOS patients compared with healthy individuals. Specifically, Fusobacterium , Ruminococcus_gnavus_group , and Escherichia-Shigella increased, while Dysosmobacter, Schaedlerella , Merdimonas , Clostridiisalibacter , Flintibacter et al. decreased in PCOS women. Regionally, Alistipes was enriched in primarily European patients, while Blautia and Roseburia...