Mitochondrial transfer balances cell redox, energy and metabolic homeostasis in the osteoarthritic chondrocyte preserving cartilage integrity

作者：Angela C. Court, Ana María Vega-Letter, Eliseo Parra-Crisóstomo, Francesca Velarde, C.M. Garcia, Alexander Ortoloff, Rolando Vernal, Carolina Pradenas, Patricia Luz‐Crawford, Maroun Khoury, Fernando Figueroa · 发表于：Theranostics · 年份：2024 · DOI：10.7150/thno.96723 · 被引用次数：60 · 研究领域：Osteoarthritis Treatment and Mechanisms

The Mitochondria transfer of MSC-derived MT induced reversal of the metabolic dysfunction by restoring the energetic status and mitochondrial dynamics in the OA chondrocyte, while conferring resistance to oxidative stress and apoptosis. Intra-articular injection of MT improved the disease in collagenase-induced OA mouse model. The restoration of the cellular homeostasis and the preclinical benefit of the intra-articular MT treatment offer a new approach for the treatment of OA.