KIF15 promotes human glioblastoma progression under the synergistic transactivation of REST and P300

作者：Wendan Yu, Shilong Han, Sheng Hu, Liyuan Ru, Chunyu Hua, Guoqing Xue, Guohui Zhang, Kuan Lv, Hanxiao Ge, Meiyi Wang, Lina Zheng, Jie Zhou, Shuai Hou, Yun Teng, Wuguo Deng, Wei Guo · 发表于：International Journal of Biological Sciences · 年份：2024 · DOI：10.7150/ijbs.98668 · 被引用次数：13 · 研究领域：RNA Research and Splicing、Cancer Mechanisms and Therapy、PARP inhibition in cancer therapy

and the combinational treatment of cell cycle inhibitor Palbociclib with P300 HAT inhibitor inhibited GBM xenografts survival more significantly. Our findings indicate that KIF15 promotes GBM progression under the synergistic transactivation of REST and P300. P300/REST/KIF15 signaling axis is expected to be served as a cascade of candidate therapeutic targets in anti-GBM.