Antioxidant vitamins’ modification of the adverse health effects induced by phthalate exposure: A scoping review of epidemiological and experimental studies

作者：Hua-Yan Mo, Chun-Han Shan, Li-wen Chen, Xin Chen, Han Chen, De Wu, Fangbiao Tao, Hui Gao · 发表于：Ecotoxicology and Environmental Safety · 年份：2024 · DOI：10.1016/j.ecoenv.2024.117190 · 被引用次数：12 · 研究领域：Effects and risks of endocrine disrupting chemicals

The exposure to and health hazards of phthalates have received abundant attention. However, reducing phthalate exposure and further decreasing the associated health risks are difficult. Nonetheless, it is important to actively seek relevant measures. Recently, antioxidant vitamins have been frequently mentioned to improve phthalate-related issues. This scoping review summarizes the existing epidemiological and experimental studies on the interaction of phthalates with antioxidant vitamins. Through a systematic search, sparse epidemiological studies explored the effects of interaction between phthalates and vitamins on reproduction, the endocrine, respiratory, and nervous system and human aging. Four prospective studies were conducted in China, the United States, Canada and Netherlands. Only one study from Netherlands focused on the female reproductive system.The other three studies focused on neurological damage to fetuses caused by phthalate exposure, and its mitigation by vitamin supplementation during pregnancy. Four cross-sectional studies were conducted based on the United States National Health and Nutrition Examination Survey database. These studies involved hazards in different systems and interactions with different vitamins. Overall, epidemiological evidence suggests that antioxidant vitamins such as vitamin A, B, D, and folic acid probably may alter the health hazards induced by phthalate exposure. Current animal studies often focus on three phthalates, DBP, DEHP a...