Clinical features and antifungal treatment of invasive Scedosporium boydii infection: report of a case and literature overview

作者：Yanping Xiao, Xiaolin Li, Longhua Hu, Yuhui Xu, Xingwei Cao, Qiaoshi Zhong · 发表于：Annals of Clinical Microbiology and Antimicrobials · 年份：2024 · DOI：10.1186/s12941-024-00754-8 · 被引用次数：4 · 研究领域：Actinomycetales infections and treatment、Antifungal resistance and susceptibility、Fungal Infections and Studies

OBJECTIVE: This study aims to present a case of persistent mycetoma caused by Scedosporium boydii and undertake a systematic literature overview to elucidate the clinical characteristics and antifungal treatment exhibited by such patients. METHODS: We report the case of a 24-year-old female who sustained a Scedosporium boydii infection in her right foot over a decade ago following a nail puncture. Concurrently, a comprehensive literature overview was conducted on PubMed, focusing on documented cases of Scedosporium boydii infections with the intent of extracting relevant clinical data. RESULTS: Our analysis revealed that post-transplantation, trauma, near drowning, corticosteroid administration, and prior surgical history were the main risk factors for Scedosporium boydii infection. Prevalent infection sites included skin/bone tissues, the central nervous system, and ocular regions. Among the 49 patients identified, 24 received itraconazole therapy and 25 received voriconazole, with no significant difference in patient outcomes (P = 0.158). Of these, 12 patients experienced treatment failure. Notably, prolonged antifungal treatment duration was identified as a protective factor against mortality in Scedosporium boydii infections [P = 0.022, OR(95%CI): 0.972(0.949-0.996)]. Conversely, a history of post-transplantation emerged as a potential risk factor for mortality[P = 0.046, OR(95%CI): 7.017(1.034-47.636)]. CONCLUSION: While uncommon, Scedosporium boydii infections carry a s...