MASLD: What We Have Learned and Where We Need to Go—A Call to Action

作者：Sedighe Hosseini Shabanan, Vitor F. Martins, Tanya Wolfson, Jake Weeks, Lael Ceriani, Cynthia Behling, Victoria Chernyak, Ahmed El Kaffas, Amir A. Borhani, Aiguo Han, Kang Wang, Kathryn J. Fowler, Claude B. Sirlin · 发表于：Radiographics · 年份：2024 · DOI：10.1148/rg.240048 · 被引用次数：27 · 研究领域：Liver Disease Diagnosis and Treatment、Liver Diseases and Immunity、Hepatocellular Carcinoma Treatment and Prognosis

Since its introduction in 1980, fatty liver disease (now termed metabolic dysfunction–associated steatotic liver disease [MASLD]) has grown in prevalence significantly, paralleling the rise of obesity worldwide. While MASLD has been the subject of extensive research leading to significant progress in the understanding of its pathophysiology and progression factors, several gaps in knowledge remain. In this pictorial review, the authors present the latest insights into MASLD, covering its recent nomenclature change, spectrum of disease, epidemiology, morbidity, and mortality. The authors also discuss current qualitative and quantitative imaging methods for assessing and monitoring MASLD. Last, they propose six unsolved challenges in MASLD assessment, which they term the proliferation, reproducibility, reporting, needle-in-the-haystack, availability, and knowledge problems. These challenges offer opportunities for the radiology community to proactively contribute to their resolution. The authors conclude with a call to action for the entire radiology community to claim a seat at the table, collaborate with other societies, and commit to advancing the development, validation, dissemination, and accessibility of the imaging technologies required to combat the looming health care crisis of MASLD.