Therapeutic peptides in the treatment of digestive inflammation: Current advances and future prospects

作者：Liangliang He, Aijing Li, Ping Yu, Shumin Qin, Hor‐Yue Tan, Denglang Zou, Haomeng Wu, Shuai Wang · 发表于：Pharmacological Research · 年份：2024 · DOI：10.1016/j.phrs.2024.107461 · 被引用次数：10 · 研究领域：Protein Hydrolysis and Bioactive Peptides、Infant Nutrition and Health、Antimicrobial Peptides and Activities

Digestive inflammation is a widespread global issue that significantly impacts quality of life. Recent advances have highlighted the unique potential of therapeutic peptides for treating this condition, owing to their specific bioactivity and high specificity. By specifically targeting key proteins involved in the pathological process and modulating biomolecular functions, therapeutic peptides offer a novel and promising approach to managing digestive inflammation. This review explores the development history, pharmacological characteristics, clinical applications, and regulatory mechanisms of therapeutic peptides in treating digestive inflammation. Additionally, the review addresses pharmacokinetics and quality control methods of therapeutic peptides, focusing on challenges such as low bioavailability, poor stability, and difficulties in delivery. The role of modern biotechnologies and nanotechnologies in overcoming these challenges is also examined. Finally, future directions for therapeutic peptides and their potential impact on clinical applications are discussed, with emphasis placed on their significant role in advancing medical and therapeutic practices.