Multi-omics insights into the microbiota-gut-brain axis and cognitive improvement post-bariatric surgery

作者：Qiaoyuan Xiang, Minhua Yu, Qi Cai, Mengjie Hu, Bo Rao, Xin Liang, Zhenxing Liu, Yu Xie, Kuan Cen, Renwei Zhang, Haibo Xu, Yumin Liu · 发表于：Journal of Translational Medicine · 年份：2024 · DOI：10.1186/s12967-024-05757-9 · 被引用次数：9 · 研究领域：Gut microbiota and health、Gastrointestinal motility and disorders、Metabolomics and Mass Spectrometry Studies

BACKGROUND: Although numerous studies have shown that bariatric surgery results in sustained weight loss and modifications in gut microbiota composition and cognitive function, the exact underlying mechanisms are unclear. This study aimed to investigate the effects of bariatric surgery on cognitive function through the microbiota-gut-brain axis (MGBA). METHODS: Demographic data, serum samples, fecal samples, cognitive assessment scales, and resting-state functional connectivity magnetic resonance imaging (rs-fMRI) scans were obtained from 39 obese patients before and after (6 months) laparoscopic sleeve gastrectomy (LSG). PCA analysis, OPLS-DA analysis, and permutation tests were used to conduct fecal 16 S microbiota profiling, serum metabolomics, and neuroimaging analyses, and a bariatric surgery-specific rs-fMRI brain functional connectivity network was constructed. Spearman correlation analysis and Co-inertia analysis were employed to correlate significant alterations in cognitive assessment scales and resting-state functional connectivity difference networks with differential serum metabolites and 16 S microbiota data to identify key gut microbiota and serum metabolic factors. RESULTS: LSG significantly reduced the weight of obese patients, with reductions of up to 28%. Furthermore, cognitive assessment scale measurements revealed that LSG enhanced cognitive functions, including memory (HVLT, p = 0.000) and executive function (SCWT, p = 0.008). Also, LSG significantly alt...