Synthesis and anti-tumor activity of new benzofuran-based chalcone derivatives as potent VEGFR-2 inhibitors

作者：Chunfei Zhang, Yixin Liu, Xiao Zhang, Chunping Wan, Zewei Mao · 发表于：RSC Medicinal Chemistry · 年份：2024 · DOI：10.1039/d4md00621f · 被引用次数：11 · 研究领域：Synthesis and biological activity、Synthesis of Organic Compounds、Click Chemistry and Applications

anti-tumor activities of them have been evaluated. The results indicated that the compounds displayed potent anticancer activity against HCC1806, HeLa and A549 cell lines. The preliminary mechanism study showed that 4g could effectively induce the apoptosis of HCC1806 cells, and showed inhibitory effect on VEFGR-2. The molecular docking study indicated that 4g had an obvious binding site with the target VEGFR-2 (PDB ID: 4BSK). Therefore, the benzofuran-based chalcone derivatives could be considered as potent VEGFR-2 inhibitors.