Association of sugar consumption with risk of depression and anxiety: a systematic review and meta-analysis

作者：JiaHui Xiong, Lu Wang, HongLu Huang, San Xiong, ShiPeng Zhang, Qinwei Fu, Rui Tang, QinXiu Zhang · 发表于：Frontiers in Nutrition · 年份：2024 · DOI：10.3389/fnut.2024.1472612 · 被引用次数：23 · 研究领域：Diet, Metabolism, and Disease、Nutritional Studies and Diet、Microbial Metabolites in Food Biotechnology

Background Sugar consumption has increased dramatically around the world, and at the same time, the prevalence of mental illnesses such as depression and anxiety continues to increase. While previous research has explored the impact of various dietary factors on mental health, the specific impact of dietary sugar consumption on the risk of depression and anxiety disorders remains elusive. This study aimed to comprehensively assess this relationship through a systematic review and meta-analysis. Methods PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Network (CNKI), and WangFang were systematically searched for studies of the association between total dietary sugar intake and risk of depression and/or anxiety. The articles that meet the criteria are screened and included in the systematic review, and the data are extracted after assessing their quality. Stata 18.0 software was used for the meta-analysis. Results Forty studies with 1,212,107 participants were included in the analysis. Results showed that sugar intake increased the risk of depression by 21% (OR = 1.21, 95% CI: 1.14, 1.27), while the overall association between sugar intake and anxiety risk was not statistically significant (OR = 1.11, 95% CI: 0.93, 1.28). Despite high heterogeneity ( I 2 = 99.7%), the results were statistically significant ( p < 0.000). Subgroup analyses showed that the association between sugar consumption and depression risk remains consistent across different...