Regional variations in cingulate cortex glutamate levels: a magnetic resonance spectroscopy study at 3 T

作者：Cassandra M. Choles, Jessica Archibald, Oscar Ortiz, Erin L. MacMillan, Niklaus Zölch, John L. K. Kramer · 发表于：Journal of Neurophysiology · 年份：2024 · DOI：10.1152/jn.00139.2024 · 被引用次数：3 · 研究领域：Advanced MRI Techniques and Applications、Functional Brain Connectivity Studies、Neuroscience and Neuropharmacology Research

In a large, sex-balanced sample of healthy individuals, we demonstrate that average regional differences (rostral to caudal) in cingulate cortex glutamate exist, using optimized experimental conditions and 3 T magnetic resonance spectroscopy techniques. Results align with observations from 7 T. A novel clustering approach was introduced to determine the number of patterns for glutamate in the healthy adult brain for the first time. These findings demonstrate that regional differences are detectable at 3 T when present and suggest the occurrence of multiple glutamate metabolism patterns in the cingulate.