Talauromides A–G, Nitrogen-Containing Heptacyclic Oligophenalenone Dimers from the Soil Fungus Talaromyces stipitatus BMC-16

作者：Shikun Zong, Yi-Xuan Zhang, Jun Xiao, Yajuan Cong, Zhao-yu Bi, Chunxiao Sun, Haotian Wang, Yimei Wei, Xiaozhi Rong, Jianfeng Zhou, Dehai Li, Meilin Zhu · 发表于：Journal of Natural Products · 年份：2024 · DOI：10.1021/acs.jnatprod.4c00742 · 被引用次数：8 · 研究领域：Microbial Natural Products and Biosynthesis、Fungal Biology and Applications、Synthetic Organic Chemistry Methods

Seven new nitrogen-containing heptacyclic oligophenalenone dimers, talauromides A–G ( 1 - 7 ), together with known compounds bacillisporins A and B ( 8 and 9 ), talaromycesones C and B ( 10 and 11 ), duclauxin ( 12 ) and lamellicolic anhydride ( 13 ), were isolated from the soil derived-fungus Talaromyces stipitatus BMC-16. Their chemical structures were determined based on spectroscopic analysis data. The absolute configurations were elucidated by chemical approaches and the comparison of CD spectra with related compounds. Compounds 3, 8 and 11 exhibited inhibitory activity on the Wnt/β-catenin signaling pathway in zebrafish embryos at a concentration of 20 μM.