Modeling lung adenocarcinoma metastases using patient-derived organoids

作者：Yuan Liu, Manendra B. Lankadasari, Joel Rosiene, Kofi E. Johnson, Juan Zhou, Samhita Bapat, Lai-Fong L Chow-Tsang, Huasong Tian, Brooke Mastrogiacomo, Di He, James G. Connolly, Harry B. Lengel, Raul Caso, Elizabeth G. Dunne, Cameron N. Fick, Gaetano Rocco, Smita Sihag, James M. Isbell, Mathew J. Bott, Bob T. Li, Piro Lito, Cameron Brennan, Mark H. Bilsky, Natasha Rekhtman, Prasad S. Adusumilli, Marty W. Mayo, Marcin Imieliński, David R. Jones · 发表于：Cell Reports Medicine · 年份：2024 · DOI：10.1016/j.xcrm.2024.101777 · 被引用次数：22 · 研究领域：Cancer Cells and Metastasis、Cancer Genomics and Diagnostics、Mathematical Biology Tumor Growth

PDOs to sotorasib demonstrates that the model can examine the efficacy of treatments to suppress metastasis and identify mechanisms of drug resistance. Finally, our PDO model cocultured with autologous peripheral blood mononuclear cells can potentially be used to determine the optimal immune-priming strategy for individual patients with LUAD.