Dual-energy CT late arterial phase iodine maps for the diagnosis of acute non-occlusive mesenteric ischemia

作者：Tommaso D’Angelo, Giuseppe M. Bucolo, İbrahim Yel, Vitali Koch, Leon D. Gruenewald, Simon S. Martin, Leona S. Alizadeh, Thomas J. Vogl, Giorgio Ascenti, Ludovica R. M. Lanzafame, Silvio Mazziotti, Alfredo Blandino, Christian Booz · 发表于：La radiologia medica · 年份：2024 · DOI：10.1007/s11547-024-01898-5 · 被引用次数：19 · 研究领域：Abdominal vascular conditions and treatments、Inflammatory Bowel Disease、Gastrointestinal Bleeding Diagnosis and Treatment

PURPOSE: To evaluate the diagnostic accuracy of dual-energy CT (DECT) iodine maps in comparison to conventional CT series for the assessment of non-occlusive mesenteric ischemia (NOMI). MATERIAL AND METHODS: We evaluated data from 142 patients (72 men; 50.7%) who underwent DECT between 2018 and 2022, with surgically confirmed diagnosis of NOMI. One board-certified radiologist performed region of interest (ROI) measurements in bowel segments on late arterial (LA) and portal venous (PV) phase DECT iodine maps as well as LA conventional series, in both ischemic and non-ischemic bowel loops, using surgical reports as reference standard, and in a control group of 97 patients. Intra- and inter-reader agreement with a second board-certified radiologist was also evaluated. Receiver operating characteristic (ROC) curve analysis was performed to calculate the optimal threshold for discriminating ischemic from non-ischemic bowel segments. Subjective image rating of LA and PV iodine maps was performed. RESULTS: DECT-based iodine concentration (IC) measurements showed significant differences in LA phase iodine maps between ischemic (median:0.72; IQR 0.52-0.91 mg/mL) and non-ischemic bowel loops (5.16; IQR 3.45-6.31 mg/ml) (P <.0001). IC quantification on LA phase revealed an AUC of 0.966 for the assessment of acute bowel ischemia, significantly higher compared to both IC quantification based on PV phase (0.951) and attenuation values evaluated on LA conventional CT series (0.828). Excelle...