Small-Molecule Therapeutics Achieve Multiple Mechanism-Mediated Sensitizations of Colorectal Cancer to Immune Checkpoint Blockade via Neutrophil Micropharmacies

作者：Xiuqi Li, Xuwentai Liu, Meng Wang, Xinyi Zhang, Ziyao Zhang, Lingjing Xue, Qianqian Xu, Juanjuan Ye, Meixi Hao, Can Zhang · 发表于：Nano Letters · 年份：2024 · DOI：10.1021/acs.nanolett.4c03678 · 被引用次数：6 · 研究领域：Immune cells in cancer、Cancer Immunotherapy and Biomarkers、Nanoplatforms for cancer theranostics

delivery barriers associated with small molecules, neutrophil micropharmacies (NOG) were developed for the codelivery of IRI and GAL, which loaded the commercial liposome formulation of IRI (ONIVYDE, ONI) intracellularly and conjugated the pH-responsive GAL liposome (GLP) on the cell surface. This neutrophil-based formulation resulted in a >4-fold increase in the ratios of the amount of both IRI and GAL accumulated in tumors to the dosage administration, effectively achieving multiple mechanism-mediated sensitization of CRC to ICB therapy.