Corrosion resistance and biocompatibility of magnesium alloy with bioactive glass-reinforced hydrogel composite coatings

作者：Rong Xu, Wuxiang Zhang, Zhenzong Shao, Yong Wang, Baolin Xu, Chenkai Zhu, Xiaochuan Wu, Chi Zhang, Qianli Gao, Bin Yu, Baiwen Hu, Dongdong Xia · 发表于：Journal of Materials Research and Technology · 年份：2024 · DOI：10.1016/j.jmrt.2024.10.111 · 被引用次数：11 · 研究领域：Bone Tissue Engineering Materials、Magnesium Alloys: Properties and Applications、Orthopaedic implants and arthroplasty

Magnesium (Mg) alloy is a promising candidate for biodegradable implants; however, its rapid degradation can create an unstable physiological environment that hampers tissue regeneration. To address this challenge, a polyvinyl alcohol (PVA) hydrogel composite reinforced with bioactive glass (BG) particles was developed as a coating for Mg alloy pellets, which underwent laser surface texturing (LST) and salting-out processes. results demonstrate that these treatments significantly enhance both the adhesiveness and swelling of the hydrogel coating. Notably, electrochemical corrosion assessments reveal a marked improvement in corrosion resistance, with the Mg–B1-L-S specimen exhibiting the highest performance after salting-out treatment. Electrochemical corrosion assessments revealed a significant enhancement in corrosion resistance for Mg alloy with the hydrogel coating, with the Mg–B1-L-S specimen showing superior performance following salting-out treatment. Immersion tests in simulated body fluid (SBF) confirmed the protective effect of the coatings, indicating that the addition of BG particles and salting-out treatment reduced mass loss and maintained pH stability. Biocompatibility evaluations through in vitro viability tests and osteogenic differentiation assays indicate that the Mg–B1-L and Mg–B1-L-S specimens exhibit superior cell activity, surface adhesion, and osteogenic potential. These findings highlight the effectiveness of PVA-BG hydrogel composite coatings in enhan...