Free‐breathing 3D cardiac extracellular volume ( ECV ) mapping using a linear tangent space alignment ( LTSA ) model

作者：Wonil Lee, Paul Kyu Han, Thibault Marin, Ismaël B. G. Mounime, Samira Vafay Eslahi, Yanis Djebra, Didi Chi, Felicitas J. Bijari, Marc D. Normandin, Georges El Fakhri, Chao Ma · 发表于：Magnetic Resonance in Medicine · 年份：2024 · DOI：10.1002/mrm.30284 · 被引用次数：5 · 研究领域：Advanced MRI Techniques and Applications、Cardiac Imaging and Diagnostics、Cardiovascular Function and Risk Factors

Abstract Purpose To develop a new method for free‐breathing 3D extracellular volume (ECV) mapping of the whole heart at 3 T. Methods A free‐breathing 3D cardiac ECV mapping method was developed at 3 T. T 1 mapping was performed before and after contrast agent injection using a free‐breathing electrocardiogram‐gated inversion recovery sequence with spoiled gradient echo readout. A linear tangent space alignment model‐based method was used to reconstruct high‐frame‐rate dynamic images from (k,t)‐space data sparsely sampled along a random stack‐of‐stars trajectory. Joint T 1 and transmit B 1 estimation were performed voxel‐by‐voxel for pre‐ and post‐contrast T 1 mapping. To account for the time‐varying T 1 after contrast agent injection, a linearly time‐varying T 1 model was introduced for post‐contrast T 1 mapping. ECV maps were generated by aligning pre‐ and post‐contrast T 1 maps through affine transformation. Results The feasibility of the proposed method was demonstrated using in vivo studies with six healthy volunteers at 3 T. We obtained 3D ECV maps at a spatial resolution of 1.9 × 1.9 × 4.5 mm 3 and a FOV of 308 × 308 × 144 mm 3 , with a scan time of 10.1 ± 1.4 and 10.6 ± 1.6 min before and after contrast agent injection, respectively. The ECV maps and the pre‐ and post‐contrast T 1 maps obtained by the proposed method were in good agreement with the 2D MOLLI method both qualitatively and quantitatively. Conclusion The proposed method allows for free‐breathing 3D ECV map...