Macrophage diversity in cancer dissemination and metastasis

作者：Alberto Mantovani, Federica Marchesi, Diletta Di Mitri, Cecília Garlanda · 发表于：Cellular and Molecular Immunology · 年份：2024 · DOI：10.1038/s41423-024-01216-z · 被引用次数：74 · 研究领域：Immune cells in cancer、Epigenetics and DNA Methylation、Cancer Cells and Metastasis

Invasion and metastasis are hallmarks of cancer. In addition to the well-recognized hematogenous and lymphatic pathways of metastasis, cancer cell dissemination can occur via the transcoelomic and perineural routes, which are typical of ovarian and pancreatic cancer, respectively. Macrophages are a universal major component of the tumor microenvironment and, in established tumors, promote growth and dissemination to secondary sites. Here, we review the role of tumor-associated macrophages (TAMs) in cancer cell dissemination and metastasis, emphasizing the diversity of myeloid cells in different tissue contexts (lungs, liver, brain, bone, peritoneal cavity, nerves). The generally used models of lung metastasis fail to capture the diversity of pathways and tissue microenvironments. A better understanding of TAM diversity in different tissue contexts may pave the way for tailored diagnostic and therapeutic approaches.