Pathogenic BALB/c mice infection model for evaluation of mpox countermeasures

作者：Lin Cheng, Wenqi Huang, Meimei Duan, Zhuohuan Li, Qi Chen, Mingxia Zhang, Zheng Zhang · 发表于：Cell Discovery · 年份：2024 · DOI：10.1038/s41421-024-00739-z · 被引用次数：23 · 研究领域：Poxvirus research and outbreaks、Bacillus and Francisella bacterial research、Yersinia bacterium, plague, ectoparasites research

The 2022 outbreak of the mpox (also known as monkeypox) rapidly spread globally, resulting in 106, 310 confirmed cases as of Aug 2024, spanning 123 countries. Although the public health emergency of international concern was discontinued in May 2023, mpox suddenly broke out one month later and spread rapidly across the mainland of China, resulting in over 1000 confirmed cases within three months. More worrying, a large-scale independent outbreak, caused by a more virulent clade I mpox virus (MPXV), emerged in the Democratic Republic of Congo in 2023. These outbreaks highlight the critical need to develop additional mpox countermeasures.