Analysis of postoperative complications and long term survival following radical gastrectomy for patients with gastric cancer

作者：Zhiyuan Yu, Liang Chen, Qixuan Xu, Rui Li, Jingwang Gao, Yunhe Gao, Wenquan Liang, Peiyu Li, Xudong Zhao, Sixin Zhou · 发表于：Scientific Reports · 年份：2024 · DOI：10.1038/s41598-024-74758-x · 被引用次数：26 · 研究领域：Gastric Cancer Management and Outcomes、Esophageal and GI Pathology、Metastasis and carcinoma case studies

This study aimed to analyze the complications and long-term survival outcomes in patients who underwent radical gastrectomy for gastric cancer, as well as to identify the risk factors associated with postoperative complications. After conducting a comprehensive search within the medical records system, a total of 2508 patients who underwent radical gastrectomy and met the inclusion criteria were enrolled. Of the 2508 patients, 301 were diagnosed with postoperative complications. The pathological data, postoperative recovery, and survival outcome were compared between complication and control group. Subsequently, univariate and multivariate logistic regression analyses were conducted to identified the risk factors. According to the Clavien-Dindo grading criteria for postoperative complications, the proportions of grade I, II, III, IV, and V complications following radical gastrectomy were observed to be 28.2%, 42.9%, 19.6%, 8.0%, and 1.3%, respectively. The presence of postoperative complications significantly prolonged the duration of gastrointestinal decompression (P < 0.001), catheter retention (P < 0.001), fasting (P < 0.001), and hospitalization (P < 0.001). Additionally, it had a detrimental impact on survival outcomes. Age > 65years [odds ratio (OR) = 1.378, P = 0.020], presence of diabetes (OR = 2.042, P < 0.001), operative duration > 215 min (OR = 1.450, P = 0.006), intraoperative blood loss > 275 ml (OR = 1.474, P = 0.004), and Roux-en-Y anastomosis for both whole st...