A biodegradable Zn–Se alloy with potent osteogenicity, antibacterial ability, and antitumor efficacy for bone-implant applications

作者：Miao Zhang, Sihan Lin, Yilong Dai, Yuncang Li, Dechuang Zhang, Cuié Wen · 发表于：Chemical Engineering Journal · 年份：2024 · DOI：10.1016/j.cej.2024.156658 · 被引用次数：14 · 研究领域：Bone Tissue Engineering Materials、Selenium in Biological Systems、Trace Elements in Health

• Zn-Se alloys were prepared using UPS with the increased solid solubility of Se in Zn. • The Zn-Se alloy exhibits good antibacterial properties against S. aureus in vitro. • Zn-1Se alloy exhibits excellent osteogenic antibacterial properties. • Zn-1Se alloy exhibits complete biosafety and excellent antitumor performance. Biodegradable zinc-selenium (Zn-Se) alloys are expected to become a competitive material for implantation into hard tissues due to the antitumor function of Se in cancer prevention and treatment. However, adding Se to Zn to create Zn-Se alloys is a challenging task due to the high volatilization of the monomeric Zn and Se elements, and the immiscibility of Se and Zn. In this study, we have successfully prepared biodegradable Zn-xSe (x = 0, 1, 3, and 5 at. %) alloys using ultrahigh pressure sintering, which effectively suppressed the volatilization of monomeric Zn and Se elements and increased the solid solubility of Se in Zn. The microstructure characteristics, mechanical properties, degradation rate, anticoagulant, osteogenic ability and antitumor properties of the ultrahigh pressure sintered (UPS) Zn-Se alloys were systematically evaluated. The microstructure of the UPS Zn-Se alloys consisted of Zn matrix phases, Zn(Se) solid solution, and ZnSe second phases formed around the elemental Se phase. The UPS Zn-1Se showed the highest compressive yield strength of ∼205.8 ± 2.3 MPa, a fracture strain of 16.4 %, a degradation rate of 44.6 ± 0.6 μm/y, effective ant...