An abstract relational map emerges in the human medial prefrontal cortex with consolidation

作者：Alon Baram, Hamed Nili, Inês Barreiros, Veronika Samborska, Timothy E.J. Behrens, Mona M. Garvert · 发表于：Current Biology · 年份：2026 · DOI：10.1016/j.cub.2026.05.068 · 被引用次数：6 · 研究领域：Memory and Neural Mechanisms

Understanding the structure of a problem, such as the relationships between stimuli, supports fast learning and flexible reasoning. Rodent work has suggested that the abstraction of structure away from sensory details occurs over the course of multiple days in the cortex. However, direct evidence of such explicit relational representations in humans is scarce, and it is unclear whether they emerge on similar timescales. Here, we combine a graph-learning paradigm with functional magnetic resonance imaging (fMRI) to look for such a relational map in the human brain. We first trained participants on two associative graphs with the same structure. We then scanned participants twice while they used this knowledge, with several days between scanning sessions. Using fMRI repetition suppression, we found an abstract relational representation in the medial prefrontal cortex (mPFC) that emerged across the two scanning sessions. This finding was also replicated using representational similarity analysis (RSA). These results shed new light on how neural representations organizing relational knowledge change with time.