Gut microbiome dysbiosis is associated with lumbar degenerative spondylolisthesis in symptomatic patients

作者：Khaled Aboushaala, Ana Chee, Darbaz Adnan, Sheila J. Toro, Harmanjeet Singh, Andrew Savoia, Ekamjeet S. Dhillon, Catherine Yuh, Jake Dourdourekas, Ishani Patel, Rajko S. Vucicevic, Alejandro A. Espinoza Orías, John T. Martin, Chun‐do Oh, Ali Keshavarzian, H Albert, Jaro Karppinen, Mehmet Koçak, Arnold Yu Lok Wong, Edward Goldberg, Frank M. Phillips, Matthew W. Colman, Frances M. K. Williams, Jeffrey A. Borgia, Ankur Naqib, Stefan J. Green, Christopher B. Forsyth, Howard S. An, Dino Samartzis · 发表于：JOR Spine · 年份：2024 · DOI：10.1002/jsp2.70005 · 被引用次数：21 · 研究领域：Gut microbiota and health、Spine and Intervertebral Disc Pathology、Spondyloarthritis Studies and Treatments

Abstract Background Lumbar degenerative spondylolisthesis (LDS), characterized as degeneration of the intervertebral disc and structural changes of the facet joints, is a condition with varying degrees of instability that may lead to pain, canal stenosis, and subsequent surgical intervention. However, the etiology of LDS remains inconclusive. Gut microbiome dysbiosis may stimulate systemic inflammation in various disorders. However, the role of such dysbiosis upon spine health remains under‐studied. The current study assessed the association of gut microbiome dysbiosis in symptomatic patients with or without LDS. Methods A cross‐sectional analysis within the framework of a prospective study was performed. DNA was extracted from fecal samples collected from adult symptomatic patients with ( n = 21) and without LDS ( n = 12). Alpha and beta diversity assessed differences in fecal microbial community between groups. Taxon‐by‐taxon analysis identified microbial features with differential relative abundance between groups. Subject demographics and imaging parameters were also assessed. Results There was no significant group differences in age, sex, race, body mass index, smoking/alcohol history, pain profiles, spinopelvic alignment, and Modic changes ( p >0.05). LDS subjects had significantly higher disc degeneration severity ( p = 0.018) and alpha diversity levels compared to non‐LDS subjects ( p = 0.002–0.003). Significant differences in gut microbial community structure were...