Advances and applications of RNA vaccines in tumor treatment

作者：Ruohan Yang, Jiuwei Cui · 发表于：Molecular Cancer · 年份：2024 · DOI：10.1186/s12943-024-02141-5 · 被引用次数：39 · 研究领域：RNA Interference and Gene Delivery、Circular RNAs in diseases、MicroRNA in disease regulation

Compared to other types of tumor vaccines, RNA vaccines have emerged as promising alternatives to conventional vaccine therapy due to their high efficiency, rapid development capability, and potential for low-cost manufacturing and safe drug delivery. RNA vaccines mainly include mRNA, circular RNA (circRNA), and Self-amplifying mRNA(SAM). Different RNA vaccine platforms for different tumors have shown encouraging results in animal and human models. This review comprehensively describes the advances and applications of RNA vaccines in antitumor therapy. Future directions for extending this promising vaccine platform to a wide range of therapeutic uses are also discussed.