Prognostic value of multi-PLD ASL-based cerebral perfusion ASPECTS in acute ischemic stroke

作者：Qingqing Li, Chaojun Jiang, Linqing Qian, Jing Yang, Tianchi Mu, Congsong Dong, Shu Wang, Zhenyu Wang, Hengheng Liu, Yijun Dong, Zhenyu Dai, Fei Chen · 发表于：Frontiers in Neurology · 年份：2024 · DOI：10.3389/fneur.2024.1476937 · 被引用次数：5 · 研究领域：Acute Ischemic Stroke Management、Intracerebral and Subarachnoid Hemorrhage Research、Cerebrovascular and Carotid Artery Diseases

Introduction We aimed to verify the application value of the Alberta Stroke Program Early CT Score (ASPECTS) based on multiple post-labeling delay (multi-PLD) arterial spin labeling (ASL) for outcome assessment in acute ischemic stroke (AIS) patients. Method The endpoint was modified Rankin scale score at 90 days (90-day mRS). Patients were divided into the good outcome (0–2) and poor outcome (3–6) groups. The independent samples t -test, Mann-Whitney U -test, and χ 2 -test were used to compare clinical and imaging parameters between groups. We used partial correlation analysis to evaluate the relationships between ASPECTS and outcomes. Multivariate logistic regression analysis was used to examine potential independent prognostic indicators. The receiver operating characteristic (ROC) curve analysis was used to evaluate the performance of the independent prognostic indicators in predicting outcomes. Results Fifty-five AIS patients were included. The good outcome group had a lower baseline National Institutes of Health Stroke Scale (NIHSS; Z = −3.413, P < 0.001) and infarct core volume (ICV; Z = −3.114, P = 0.002) as well as higher cerebral blood flow (CBF)-ASPECTS ( Z = −3.835, P < 0.001) and cerebral blood volume (CBV)-ASPECTS ( Z = −4.099, P < 0.001). Higher CBF-ASPECTS ( r = −0.459, P = 0.001), and CBV-ASPECTS ( r = −0.502, P < 0.001) were associated with a lower 90-day mRS. The baseline NIHSS, CBF-ASPECTS, and CBV-ASPECTS were identified as ind...