Revisiting the association between pretreatment thrombocytosis and cancer survival outcomes: an umbrella review of meta-analyses

作者：Chi Shu, Xiran Wang, Changtao Li, Jun Huang, Xuan Xie, Hong Li, Jichun Zhao, Ziqiang Wang, Yazhou He, Yanhong Zhou · 发表于：BMC Cancer · 年份：2024 · DOI：10.1186/s12885-024-13027-6 · 被引用次数：7 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Myeloproliferative Neoplasms: Diagnosis and Treatment、Erythropoietin and Anemia Treatment

BACKGROUND: Although associations have been reported linking pretreatment thrombocytosis to cancer survival outcomes, the validity and strength of existing observational evidence have been contested. This study aimed to conduct an umbrella review to comprehensively appraise the strength, validity and credibility of these reported associations. METHODS: We searched Medline, Embase and Cochrane Database of Systematic Reviews from inception to 8 April 2023 to retrieve meta-analyses of observational studies. Meta-analyses were re-performed using a random-effect model and the strength of evidence was graded as convincing, highly suggestive, suggestive and weak according to seven pre-defined quantitative criteria reflecting statistical significance, amount of data, heterogeneity, and evidence of bias. The quality of review was appraised using the AMSTAR2 checklist. The umbrella review was reported adhering to the PRISMA guideline and was registered on PROSPERO (CRD42023455391). RESULTS: /L) to define thrombocytosis. Although evidence appraisal did not identify convincing evidence (Class I), the associations of thrombocytosis with inferior overall survival of lung, gastric, colorectal cancer and malignant mesothelioma were classified as highly suggestive evidence (Class II). According to AMSTAR2 ratings, no meta-analysis was identified with high or moderate quality. CONCLUSIONS: Our findings consolidated the association between pretreatment thrombocytosis and poor survival outcomes ...