The Rapidly Evolving Landscape of DCD Heart Transplantation

作者：Yashutosh Joshi, Katherine Wang, Campbell MacLean, Jeanette E. Villanueva, Ling Gao, Alasdair Watson, Arjun Iyer, M. Connellan, Emily Granger, P. Jansz, Peter S. Macdonald · 发表于：Current Cardiology Reports · 年份：2024 · DOI：10.1007/s11886-024-02148-w · 被引用次数：12 · 研究领域：Transplantation: Methods and Outcomes、Organ Transplantation Techniques and Outcomes、Mechanical Circulatory Support Devices

PURPOSE OF REVIEW: To summarise current international clinical outcomes from donation after circulatory death heart transplantation (DCD-HT); discuss procurement strategies, their impact on outcomes and overall organ procurement; and identify novel approaches and future areas for research in DCD-HT. RECENT FINDINGS: Globally, DCD-HT survival outcomes (regardless of procurement strategy) are comparable to heart transplantation from brain dead donors (BDD). Experience with normothermic machine perfusion sees improvement in rates of primary graft dysfunction. Techniques have evolved to reduce cold ischaemic exposure to directly procured DCD hearts, though controlled periods of cold ischaemia can likely be tolerated. There is interest in hypothermic machine perfusion (HMP) for directly procured DCD hearts, with promising early results. Survival outcomes are firmly established to be equivalent between BDD and DCD-HT. Procurement strategy (direct procurement vs. regional perfusion) remains a source of debate. Methods to improve allograft warm ischaemic tolerance are of interest and will be key to the uptake of HMP for directly procured DCD hearts.