CX3CR1 + CD8 + T cells: Key players in antitumor immunity

作者：Jiajin Ma, Yue Wu, Shaoxian Wu, Fang Zhang, Lujun Chen, Jingting Jiang, Xiao Zheng · 发表于：Cancer Science · 年份：2024 · DOI：10.1111/cas.16359 · 被引用次数：11 · 研究领域：Immunotherapy and Immune Responses、Chemokine receptors and signaling、Cancer Immunotherapy and Biomarkers

Abstract CX3CR1 functions as the specific receptor for the chemokine CX3CL1, demonstrating expression across a broad spectrum of immune cells. This underscores its pivotal role in communication and response mechanisms within the immune system. Upon engagement with CX3CL1, CX3CR1 initiates a cascade of downstream signaling pathways that regulate various biological functions. In the context of tumor progression, the intricate and inhibitory nature of the tumor microenvironment presents a significant challenge to current clinical treatment techniques. This review aims to comprehensively explore the tumor‐destructive potential shown by CX3CR1 + CD8 + T cells. Simultaneously, it investigates the promising prospects of utilizing CX3CR1 in future tumor immunotherapies.