Light-Driven N-Heterocyclic Carbene-Catalyzed Multi-Component Reaction for the Synthesis of β-Amino Ketones

作者：Chengcheng Shi, Nan Zhong, Lin Guo, Jiawen Yin, Chao Yang, Wujiong Xia · 发表于：Organic Letters · 年份：2024 · DOI：10.1021/acs.orglett.4c03288 · 被引用次数：8 · 研究领域：Catalytic C–H Functionalization Methods、Radical Photochemical Reactions、Sulfur-Based Synthesis Techniques

A N-heterocyclic carbene-catalyzed (NHC) three-component reaction involving N -aminopyridinium salts, alkenes, and aldehydes for the synthesis of β-amino ketones is described. In this reaction, N -aminopyridinium salts and the Breslow intermediate, which is generated from NHC and aldehydes, are utilized to undergo a single-electron transfer process, forming a ketyl radical intermediate and amidyl radicals. Subsequent to the formation of the amidyl radical, it undergoes selective capture by alkenes, followed by radical cross-coupling to yield the desired β-amino ketones.