Calcitonin gene-related peptide promotes epithelial reparative and anticolitic functions of IL-4 educated human macrophages

作者：Blanca E. Callejas, James A. Sousa, Kyle L. Flannigan, Arthur Wang, Eve Higgins, Aydin Herik, Shuhua Li, Sruthi Rajeev, Ryan E. Rosentreter, Remo Panaccione, Derek M. McKay · 发表于：American Journal of Physiology-Gastrointestinal and Liver Physiology · 年份：2024 · DOI：10.1152/ajpgi.00159.2024 · 被引用次数：5 · 研究领域：Neuropeptides and Animal Physiology、Cancer, Stress, Anesthesia, and Immune Response、Immune Response and Inflammation

A novel pathway is identified whereby interleukin-4-educated human macrophages [M(IL4)s] exposed to calcitonin gene-related peptide (CGRP) reduce oxazolone-induced colitis and promote epithelial wound healing in vitro through COX1-dependent signaling. Support is provided for the concept of macrophage transfer to treat enteric inflammation where neuroimmune interaction, in this case CGRP neuropeptide, produced under inflammatory conditions will reinforce the anticolitic and wound repair capacity of M(IL4) autologous-based therapy for IBD treatment.