Catalyst‐Free, Radical Tri‐ and Difluoromethylation of Isocyanides and N ‐Arylacrylamides Using Rotating Magnetic Field and Metal Rods

作者：Xuliang Han, Haodong Liu, Xiaomei Feng, Fuchao Jia, Zengdian Zhao, Xinjin Li · 发表于：Chinese Journal of Chemistry · 年份：2024 · DOI：10.1002/cjoc.202400854 · 被引用次数：19 · 研究领域：Fluorine in Organic Chemistry、Inorganic Fluorides and Related Compounds、Radical Photochemical Reactions

Comprehensive Summary The pursuit of sustainable and environmentally benign synthetic methods continues to challenge organic chemists. Herein, we introduce a magnetoredox system for tri‐ and difluoromethylation of isocyanides and N ‐arylacrylamides using a rotating magnetic field and steel rods. This magnetoredox approach enables facile synthesis of functionalized phenanthridines and oxindoles without the need for catalysts and additives under mild conditions. Such a system potentially represents an attractive strategy for selective formation of bonds through multifaceted regulation of magnetic intensity, rotating frequency, and rod size.