Intelligent Hydrogel with Physiologically Dependent Capacities of Photothermal Conversion and Nanocatalytic Medicine to Integratively Inhibit Bacteria and Inflammation for On‐Demand Treatment of Infected Wound

作者：Wenyun Mu, Jie Liu, Handan Zhang, Lin Weng, Tao Liu, Xin Chen · 发表于：Small · 年份：2024 · DOI：10.1002/smll.202405464 · 被引用次数：16 · 研究领域：Wound Healing and Treatments、Nanoplatforms for cancer theranostics、Electrospun Nanofibers in Biomedical Applications

Abstract Although chemodynamic therapy (CDT) and photothermal therapy (PTT) based on a variety of nanoparticles have been developed to achieve effective anti‐bacterial therapy, the limited therapeutic efficiency of CDT alone, as well as the undifferentiated damage of PTT to both bacteria and surrounding healthy tissue are still challenges for their clinical application of infected wounds treatments. In addition, during the CDT and PTT‐mediated antimicrobial processes, the endogenous macrophages would be easily converted to pro‐inflammatory macrophages (M1 phenotype) under local ROS and hyperthermia to promote inflammation, resulting in unexpected suppression of tissue regeneration and possible wound deterioration. To address these problems, a biodegradable sodium alginate/hyaluronic acid hydrogel loaded with functional CeO 2 ‐Au nano‐alloy (AO@AC P ) is fabricated to not only achieve precise and efficient antibacterial activity through infection‐environment dependent photothermal‐chemodynamic therapy but also rapidly eliminate the excess reactive oxygens (ROS) in the M1 type macrophage at the infected area to induce their polarization to M2 type for significant inhibition of inflammation and remarkable enhancement of tissue regeneration, hopefully developing an effective strategy to treat infected wound.