Development of a risk prediction model for the first occurrence of thrombosis in patients with OAPS

作者：Jie Gao, Yan Zheng, Zhuo Wang, Junfeng Jia, Jian‐Bo Wan, Qing Han, Xi Zheng, Renli Liu, Zhaohui Zheng, Kaichun Wu, Ping Zhu · 发表于：Frontiers in Immunology · 年份：2024 · DOI：10.3389/fimmu.2024.1459548 · 被引用次数：4 · 研究领域：Systemic Lupus Erythematosus Research、Pregnancy and preeclampsia studies、Blood Coagulation and Thrombosis Mechanisms

Objectives: The aim of this study is to assess the risk factors associated with thrombotic events in obstetric antiphospholipid syndrome (OAPS) patients and to develop a predictive model specifically tailored to predict the risk of postpartum thrombosis in OAPS patients without prior thrombotic events. This research seeks to enhance clinician's awareness regarding the postpartum care and monitoring of OAPS patients. Methods: A retrospective study was conducted at the First Affiliated Hospital of the Fourth Military Medical University including 269 consecutive inpatients diagnosed with antiphospholipid syndrome (APS) from July 1, 2008 to July 31, 2022. All participants met the 2006 Sydney APS classification criteria or the "non-criteria OAPS classification". Out of 98 candidate clinical and laboratory parameters considered, 40 potential variables were selected for analysis based on expert opinion. The logistic regression mode with the Least Absolute Shrinkage and Selection Operator (LASSO) were used to identify optimal predictive characteristics. All samples were included in the model building and a nomogram was generated based on these characteristics. The differentiation, calibration, and clinical utility of the predictive model were evaluated using the area under the curve (AUC), calibration curve, and decision curve analysis. The model was also validated by a 1000 bootstrap tests. Results: 126 patients with OAPS were enrolled, and a total of 89 OAPS patients who had never ...