Efficacy and safety of olverembatinib in adult BCR :: ABL1 ‐positive ALL with T315I mutation or relapsed/refractory disease

作者：Weiyang Liu, Cheng Wang, Wanyan Ouyang, Jie Hao, Jiayi Ren, Lijun Peng, Sijie Tang, Yuanfang Liu, Yongmei Zhu, Xiangqin Weng, Duohui Jing, Sai‐Juan Chen, Jin Wang, Jian‐Qing Mi · 发表于：British Journal of Haematology · 年份：2024 · DOI：10.1111/bjh.19804 · 被引用次数：15 · 研究领域：Chronic Myeloid Leukemia Treatments、Acute Lymphoblastic Leukemia research、Chronic Lymphocytic Leukemia Research

Third-generation tyrosine kinase inhibitors (TKIs) have much potential for the treatment of BCR::ABL1-positive leukaemia, particularly that harbouring the ABL1 T315I mutation. Olverembatinib (HQP1351), a novel third-generation TKI, has favourable efficacy and safety profiles in chronic myeloid leukaemia. Here, we present the clinical findings from 31 BCR::ABL1-positive acute lymphoblastic leukaemia (ALL) patients who received olverembatinib. Among the 14 patients with overt relapsed/refractory (R/R) disease (including 10 with the T315I mutation), 71.4% achieved an overall response. Of the other 17 patients with minimal residual disease (MRD)-positive ALL (including 14 with the T315I mutation), 60.0% and 47.1% achieved MRD flow negativity and complete molecular remission, respectively. With a median follow-up time of 16.3 months, the median event-free survival and overall survival were 3.9 and 8.3 months respectively, in overt R/R patients, and 11.5 and 18.4 months in MRD-positive patients. Allogeneic haematopoietic stem cell transplantation further improved outcomes among responders. The safety profile was generally manageable. This study suggests that olverembatinib-based therapy is another promising option for BCR::ABL1-positive ALL in addition to ponatinib, especially for patients with MRD-positive disease and a single T315I mutation.