Design and Synthesis of Fluorine-Containing Embedded Carbon Dots Stationary Phase for Separation of Versatile Analytes

作者：Zhihua Song, Wenpu Wu, Sui Lei, Xinyan Han, Hui Xu, Gangqiang Yang, Peng Zhang, N. Zhou, Lingxin Chen, Jinhua Li · 发表于：Analytical Chemistry · 年份：2024 · DOI：10.1021/acs.analchem.4c02411 · 被引用次数：21 · 研究领域：Carbon and Quantum Dots Applications、Analytical chemistry methods development、Luminescence and Fluorescent Materials

Thus far, numerous new stationary phases have been developed. A fluorine-containing embedded carbon dots (F3-CDs-SiO 2 ) stationary phase was first designed and synthesized. The resulting F3-CDs-SiO 2 stationary phase was characterized carefully by scanning electron microscopy, transmission electron microscopy, elemental analysis, X-ray photoelectron spectroscopy, and Brunauer–Emmett–Teller experiment. The F3-CDs-SiO 2 stationary phase was slurry packed into the HPLC column (150 × 2.1 mm) for evaluation. Furthermore, the F3-CDs-SiO 2 column was successfully used for separation of pesticides, nucleosides, sulfonamides, alkaloids, and alkylbenzenes. The retention mechanism (including hydrophobic interaction, F–F, hydrogen bond interaction, ion-exchange, dipole–dipole interaction, electrostatic interaction, etc.) was investigated carefully. Meanwhile, the F3-SiO 2 stationary phase was synthesized and used to evaluate the role of CDs. Furthermore, various commercial stationary phases (including amino-SiO 2, diol-SiO 2, C18-SiO 2, and PFP-SiO 2 ) were used for comparison. Moreover, the F3-CDs-SiO 2 column possessed good repeatability, reproducibility, and stability in separation of versatile analytes.