Wnt/β-Catenin Signaling and Congenital Abnormalities of Kidney and Urinary Tract

作者：Cuicui Yu, Bixia Zheng, Luyan Zhang, Aihua Zhang, Zhanjun Jia, Guixia Ding · 发表于：Kidney Diseases · 年份：2024 · DOI：10.1159/000541684 · 被引用次数：5 · 研究领域：Renal and related cancers、Wnt/β-catenin signaling in development and cancer、Genetic and Kidney Cyst Diseases

Background: Precise regulation of cell-cell communication is vital for cell survival and normal function during embryogenesis. The Wnt protein family, a highly conserved and extensively studied group, plays a crucial role in key cell-cell signaling events essential for development and regeneration. Congenital anomalies of the kidney and urinary tract (CAKUT) represent a leading cause of chronic kidney disease in children and young adults, and include a variety of birth abnormalities resulting from disrupted genitourinary tract development during embryonic development. The incidence and progression of CAKUT may be related to the Wnt signal transduction mechanism. Summary: This review provides a comprehensive overview of the classical Wnt signaling pathway's role in CAKUT, explores related molecular mechanisms and provides new targets and intervention methods for the future treatment of the disease. Key Messages: The Wnt signal is intricately engaged in a variety of differentiation processes throughout kidney development.